The educational sector plays a key role in meeting Europe’s sustainability challenges and promoting inclusive growth and teachers are at the forefront of preparing future generations of children and lifelong learners. The recent surge in the use of Artificial Intelligence (AI) in education has called this role into question. For this reason, the TAICo project has set out to develop, implement, and validate a model of Teacher-AI Complementarity that applies broadly across educational domains and teaching professions. This model will aim to enhance our understanding of the potential impacts of AI in aligning with human skills for teaching and learning. We will apply and assess AI technologies in several field studies in six authentic educational settings. This will allow us to derive practical and evidence-based guidelines for all stakeholders involved (including teachers, educational institutions, EdTech industry and policy makers) and significantly contribute to the productive and ethical integration of AI in education. The project will actively engage these stakeholders in participatory design activities to shape the future agenda of how AI is developed, teachers are prepared and European policies respond to the future challenges of an AI-enhanced educational system.