Pharmacological Versus Non-Pharmacological Interventions for the Treatment of Major Depressive Disorder

A systematic review to support clinical practice guidelines on the pharmacological versus non-pharmacological treatments of major depressive disorder (MDD). The systematic review is structured in two parts: Part 1: Update of the 2015 Agency for Healthcare Research and Quality (AHRQ) report on pharmacological versus non-pharmacological treatments.[1] Conduct of two rapid reviews on values and preferences of patients with MDD and cost effectiveness of MDD treatments. Part 2: Additional literature searches to build a network meta-analyses model and conduct network meta-analyses of pharmacological versus non-pharmacological treatments.