The EUCanScreen project aims to implement high-quality screening programs for breast, cervical and colorectal cancer as well as recommended screening tests for lung, prostate and stomach cancer in Europe on a sustainable basis. The aim is to reduce the burden of cancer and improve health equity in the EU. A total of 29 countries are involved, including 25 EU Member States as well as Ukraine, Moldova, Norway and Iceland. The project is coordinated by the University of Latvia. The Center for Evaluation leads the evaluation work package. The purpose of the evaluation is to enable accountability and continuous improvement through data-driven and systematic documentation of achievements, accomplishments, challenges and potential for improvement. The evaluation supports accountability by documenting the implementation of the planned activities, assessing the quality of the results and recording changes in the cancer screening programs of the participating countries. It also optimizes implementation by conducting a strengths-weaknesses-opportunities-risk analysis, implementing continuous feedback processes and documenting lessons learned. The evaluation approach is comprehensive and multi-layered. It includes the evaluation at project level (implementation, quality, cooperation), national level (policies, practices, programmes) and European level (strategies, guidelines, harmonization). In addition, the perspectives of relevant stakeholders and target groups (accessibility, equal opportunities) are included. Methodologically, a combination of qualitative (interviews, document analysis) and quantitative (surveys, monitoring) approaches will be used. Funded by the European Union