Inflammation, Sepsis, and Regeneration: Development of Efficient Diagnostic Methods and New Therapeutic Approaches in Inflammation and Sepsis

Sepsis is a life-threatening organ dysfunction resulting from a severe systemic inflammation caused by an infection. Worldwide, approximately 31.5 million sepsis cases occur annually with a mortality of up to 50% in septic shock. The development of supportive sepsis therapies remains a major challenge due to the complex pathogenesis of this inflammatory syndrome and due to the vast heterogeneity of septic patients. The aims of this project are (i) to improve the diagnostic potential of sepsis by establishing new biomarkers for systemic infections, in particular, the role of extracellular vesicles; (ii) to investigate the central role of the endothelium in sepsis; and (iii) to study the effect of inflammatory mediator modulation by extracorporeal adsorption therapies in sepsis patients.