Andrea De Luna

Assoz. Prof. Mag. Andrea De Luna, PhD

Center for Regenerative Medicine

Projects (Extract Research Database)

Running projects

3D printing of extracellular vesicles from Hoffa fat pad derived mesenchymal stem cells for cartilage regeneration

Duration: 01/06/2024–31/05/2027
Principle investigator for the project (University for Continuing Education Krems): Andrea De Luna
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)

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Completed projects

Extracellular vesicles from Hoffa´s fat pad- a new strategy for cartilage regeneration

Duration: 01/03/2020–28/02/2023
Principle investigator for the project (University for Continuing Education Krems): Andrea De Luna
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program: Life Science Call NFB

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The Role of microvesicles from blood derived products in osteoarthritis

Duration: 01/01/2018–29/02/2020
Principle investigator for the project (University for Continuing Education Krems): Andrea De Luna
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program: Technologieförderung NÖ

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Durchführbarkeitsstudie des Serumisolators hypACT

Duration: 02/05/2017–31/05/2017
Principle investigator for the project (University for Continuing Education Krems): Andrea De Luna
Funding: Unternehmen
Program: ---

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Identification of novel treatment options for osteoarthritis

Duration: 05/11/2012–30/04/2016
Principle investigator for the project (University for Continuing Education Krems): Stefan Nehrer
Funding: Bundesländer (inkl. deren Stiftungen und Einrichtungen)
Program: Life Science Call NFB

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Publications (Extract Research Database)

Otahal, A.; Kramer, K.; Neubauer, M.; Gulová, S.; Lacza, Z.; Nehrer, S.; De Luna, A. (2024). Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production. Stem Cell Research and Therapy, 15: https://doi.org/10.1186/s13287-024-03681-9

Neubauer, M.; Otahal, A.; Kuten, S.; Sherman, S.L.; Moser, L.; Kramer K.; DeLuna, A.; Neugebauer, J.; Dammerer, D.; Muellner, T.; Nehrer, S. (2023). Infra-patellar fat pad-derived mesenchymal stem cells maintain their chondrogenic dif-ferentiation potential after arthroscopic harvest with blood-product supplementation. Int Orthop., 30: doi: 10.1007/s00264-023-05930-7

Otahal, A.; De Luna, A.; Mobasheri, A.; Nehrer, S. (2023). Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy. In: Humana Press, Cartilage Tissue Engineering: 123-140, Springer Protocols, United States of America

Otahal, A.; Tischer, T.; De Luna, A.; Nehrer, S. (2023). Plättchenreiches Plasma und andere Blutprodukte – neue Forschungsaspekte zur Wirkung von Blutderivaten und klinische Ergebnisse bei Gonarthrose. Knie Journal, 5(3): 142–149, Springer

Kuten-Pella, O.; De Luna, A.; Kramer, K.; Neubauer, M.; Nehrer, S.; Lacza, Z. (2021). Regenerative Potential of Blood-Derived Products in 3D Osteoarthritic Chondrocyte Culture System. Curr Issues Mol Biol, 43(2): 665-675

Olmos Calvo, I.; Kuten-Pella, O.; Kramer, K.; Madár, À.; Takács, S.; Kardos, D.; Simon, D.; Erdö-Bonyár, S.; Berki, T.; De Luna, A.; Nehrer, S.; Lacza Z. (2021). Optimization of Lyophilized Hyperacute Serum (HAS) as a Regenerative Therapeutic in Osteoarthritis. Int J Mol Sci, 22 (14): 7496

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Moser, L.; Neubauer, M.; Lacza,Z.; Nehrer, S.; De Luna, A. (2021). Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model. Int J Mol Sci., 22(13): 7224

Otahal, A.; Kuten-Pella, O.; Kramer, K.; Neubauer, M.; Lacza, Z.; Nehrer, S.; De Luna, A. (2021). Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products. Sci Rep., 12;11(1): 5823

De Luna, A.; Otahal, A.; Nehrer, S. (2020). Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration? Frontiers in Cell and Developmental Biology, 8:593386: 10.3389/fcell.2020.593386

Otahal, A.; Kramer, K.; Kuten-Pella, O.; Weiss, R.; Stotter, C.; Lacza, Z.; Weber, V.; Nehrer, S.; De Luna, A. (2020). Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol, Sep 25: 584050

Kuten, O.; Simon, M.; Hornyák, I.; De Luna-Preitschopf, A.; Nehrer, S.; Lacza, Z. (2018). The Effects of Hyperacute Serum on Adipogenesis and Cell Proliferation of Mesenchymal Stromal Cells. Tissue Engineering Part A, Vol. 24, No. 11-12: doi: 10.1089/ten.TEA.2017.0384

De Luna-Preitschopf, A.; Zwickl, H.; Nehrer, S.; Hengstschläger, M.; Mikula, M. (2017). Rapamycin Maintains the Chondrocytic Phenotype and Interferes with Inflammatory Cytokine Induced Processes. International Journal of Molecular Sciences, 18(7): doi:10.3390/ijms18071494

Preitschopf, A.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Zwickl, H.; Rosner, M.; Joó, J.G.; Nehrer, S; Hengstschläger, M; Mikula, M. (2016). Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells. Stem Cells Translational Medicine: 580-90

Schörghofer, D.; Kinslechner, K.; Preitschopf, A.; Schütz, B.; Röhrl, C.; Hengstschläger, M.; Stangl, H.; Mikula, M. (2015). The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence . Reprod Biol Endocrinol, Vol. 13, No. 88

Üstün, S.; Lassnig, C.; Preitschopf, A.; Mikula, M.; Müller, M.; Hengstschläger, M.; Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transplantation Immunology: 45-50

Üstün, S.; Lassnig, C.; Preitschopf, A.; Mikula, M.; Müller, M.; Hengstschläger, M.; Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transpl Immunol.

Preitschopf, A.; Zwickl, H.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Rosner, M.; Joo, G.J.; Hengstschläger, M.; Nehrer, S.; Mikula, M. (2015). Rapamycin enhances Sox9 Expression during Chondrogenic Differentiation of Amniotic Fluid Stem Cells. Tissue Engineering Part A, September 2015, Volume 21, Supplement 1: 192

Preitschopf, A.; Zwickl, H.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Rosner, M.; Joó, J.; Hengstschläger, M.; Nehrer, S.; Mikula, M. (2015). Rapamycin enhances SOX9 expression during chondrogenic differentiation of amniotic fluid stem cells. Tissue Engineering Part A: 192-93

Preitschopf, A.; Li, K.; Schörghofer, D.; Kinslechner, K.; Schütz, B.; Thi Thanh Pham, H.; Rosner, M.; Joo, G.; Röhrl, C.; Weichhart, T.; Stangl, H.; Lubec, G.; Hengstschläger, M.; Mikula, M. (2014). mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression. Plos One

Preitschopf, A.; Busch, J.; Zwickl, H.; Nehrer, S.; Hengstschläger, M.; Mikula, M. (2014). Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects. In: Perinatal Stem Cells: 87-98, Springer Verlag

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Lectures (Extract Research Database)

Extracellular vesicles from Hoffa Fat Pad derived MSC - silver linings for cartilage repair?

Jahrestagung des Vienna Center for Engineering in Medicine, 13/12/2023

Extracellular vesicles from Hoffa Fat Pad derived mesenchymal stem cells – friends or foe?

Webinar of the Italian Society of Stem Cells, 04/07/2023

Extracellular vesicles from Hoffa Fat Pad MSCs favor the osteoarthritic phenotype of chondrocytes

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 03/05/2023

Extracellular vesicles in blood derived products

ICRS World Congress, 12/04/2023

Isolation and culture of Hoffa-derived adipose MSCs for extracellular vesicle production in a vertical wheel bioreactorÖGMBT W

ÖGMBT Workshop „Advanced Cell Culture Technologies", 17/03/2023

Extracellular vesicles from blood derived products for cartilage repair

ASEV/GSEV Joint Meeting, 28/10/2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair? - a status report

Annual Meeting of the Austrian Cluster of Tissue Regeneration, 27/04/2022

Extracellular Vesicles in Blood-Derived Products for Cartilage Repair

ICRS World Congress, 14/04/2022

Effects of extracellular vesicles from blood derivatives on osteoarthritic chondrocytes

ASEV/GSEV Joint Meeting, Freising, Deutschland, 28/11/2019

Anti-coagulation influences properties of extracellular vesicles isolated from autologous blood derived products used for cartilage repair

World Congress of the International cartilage repair and joint preservation society, Vancouver, Kanada, 08/10/2019

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